Comparison of premedication with 75 mg and 150 mg pregabalin for postoperative analgesia in total hysterectomy patients - A randomised control trial

Pregabalin is an anticonvulsant, structural analogue of Gamma Amino Butyric Acid (GABA) and very much efficient in the management neuropathic pain incisional injury. The aim this research to evaluate efficacy preoperative administration pregabalin on postoperative analgesic requirement subjects undergoing total abdominal hysterectomy under spinal anaesthesia. : A randomized, placebo-controlled trial was conducted 129 patients anaesthesia, divided three groups (placebo group, 75 mg 150 pregabalin) 43 each. Pre-operative Ramsay sedation scale noted post-operative VAS score for at rest cough 30 minutes, 1hr, 2 hrs, 6 12 hrs 24 post operatively noted. Time rescue analgesics day one assessed. operative scores reduced with dose pregabalin. Sleep also significantly better as increases. need analgesia decreased As increases, side effects Dizziness, Nausea vomiting has been found reduce effectively, reduces improves sleep pattern. are high a 300 mg. Therefore advocated